Wound Healing: A New Understanding of the Drama

~ Exam ~

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This test has 15 questions.

All questions must be answered before the test can be graded.

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1. Quiescent tissues include all of the following except:

  a. Liver

  b. Kidney

  c. Pancreas

  d. Heart

2. Which of the following cells plays a central role in scar formation?

  a. Eosinophil

  b. Mast cell

  c. Fibroblast

  d. Dendritic cell

3. The most important role of transforming growth factor beta (TGF- beta) in wound healing is:

  a. Promotion of fibrosis

  b. Attraction of neutrophils

  c. Activation of macrophages

  d. Promotion of angiogenesis

4. The end result of receptor mediated signal transduction is:

  a. Cell death

  b. A change in gene expression

  c. Influx of calcium into the cell

  d. Neoplastic transformation

5. In which phase of the cell cycle is DNA synthesized?

  a. G1

  b. S

  c. G2

  d. M

6. Which of the following is a function of the extracellular matrix?

  a. Imparts resilience to soft tissues and bone

  b. Stores growth factors

  c. Acts as a scaffold for migrating cells

  d. Facilitates cell growth

  e. All of the above

7. An injury to a continuously dividing tissue (such as oral mucosa) that disrupts the underlying stromal framework will result in:

  a. Regeneration

  b. Scarring

8. Which of the following is true of first-intention wounds?

  a. Relatively larger that second-intention wounds

  b. Healing is generally slow

  c. Inflammation is abundant

  d. Scarring is minimal

9. What happens first in the immediate aftermath of a wound?

  a. Neutrophils flood the damaged tissue

  b. Exposed collagen activates coagulation

  c. Epithelial cells begin to proliferate at the margins

  d. Macrophages enter the damaged tissue

  e. Fibroblasts secrete collagen

10. When does granulation tissue appear?

  a. Within the first few days after a wound occurs

  b. At approximately 10 days after a wound occurs

  c. Between two and three weeks after a wound occurs

  d. When the final scar is being formed

11. A scar has more tensile strength than normal skin.

  a. True

  b. False

12. A mature scar is composed of:

  a. Fibrin

  b. Elastin

  c. Collagen

  d. Smooth muscle

13. An insufficiency of which vitamin causes the formation of unstable collagen?

  a. A

  b. B

  c. C

  d. D

  e. E

14. What is the single most important cause of delayed wound healing?

  a. Diabetes

  b. Drug side effects

  c. Foreign bodies

  d. Size of the wound

  e. Infection

15. Keloids contain an excess of:

  a. Collagen

  b. Fibrin

  c. Granulation tissue

  d. Blood vessels

  e. Inflammation